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Q76MZ3

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Q76MZ3)

Uniprot ID Q76MZ3
Protein Name Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Gene Name Ppp2r1a
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.672
Function The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:10100624). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). .
GO - Molecular function
  • protein antigen binding : ISO:MGI
  • protein heterodimerization activity : ISO:MGI
  • protein phosphatase regulator activity : IEA:InterPro
  • protein serine/threonine phosphatase activity : IDA:MGI
GO - Biological process
  • chromosome segregation : ISS:UniProtKB
  • female meiotic nuclear division : IMP:MGI
  • meiotic sister chromatid cohesion, centromeric : IMP:MGI
  • meiotic spindle elongation : IMP:MGI
  • mitotic sister chromatid separation : IMP:MGI
  • peptidyl-serine dephosphorylation : IDA:MGI
  • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand : IMP:MGI
  • protein-containing complex assembly : IEA:InterPro
  • regulation of meiotic cell cycle process involved in oocyte maturation : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.