Eukaryotic translation initiation factor 2 subunit 1 (Q6ZWX6)

Uniprot ID Q6ZWX6
Protein Name Eukaryotic translation initiation factor 2 subunit 1
Gene Name Eif2s1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.124
Function Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). .
GO - Molecular function
  • ribosome binding : ISS:UniProtKB
  • translation initiation factor activity : ISS:UniProtKB
GO - Biological process
  • aging : ISO:MGI
  • cellular response to amino acid starvation : IDA:UniProtKB
  • cellular response to heat : ISO:MGI
  • cellular response to oxidative stress : IMP:ARUK-UCL
  • cellular response to UV : IDA:UniProtKB
  • negative regulation of guanyl-nucleotide exchange factor activity : ISO:MGI
  • negative regulation of translational initiation in response to stress : IDA:UniProtKB
  • positive regulation of neuron death : ISO:MGI
  • positive regulation of type B pancreatic cell apoptotic process : ISO:MGI
  • protein autophosphorylation : IDA:MGI
  • regulation of translational initiation in response to stress : IDA:MGI
  • response to endoplasmic reticulum stress : IDA:UniProtKB
  • response to manganese-induced endoplasmic reticulum stress : IEA:Ensembl
  • stress granule assembly : IMP:ARUK-UCL
  • translation : IDA:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.