| Signal peptide(a) |
N |
Secretome P(b) |
0.124 |
| Function |
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). . |
| GO - Molecular function |
- ribosome binding : ISS:UniProtKB
- translation initiation factor activity : ISS:UniProtKB
|
| GO - Biological process |
- aging : ISO:MGI
- cellular response to amino acid starvation : IDA:UniProtKB
- cellular response to heat : ISO:MGI
- cellular response to oxidative stress : IMP:ARUK-UCL
- cellular response to UV : IDA:UniProtKB
- negative regulation of guanyl-nucleotide exchange factor activity : ISO:MGI
- negative regulation of translational initiation in response to stress : IDA:UniProtKB
- positive regulation of neuron death : ISO:MGI
- positive regulation of type B pancreatic cell apoptotic process : ISO:MGI
- protein autophosphorylation : IDA:MGI
- regulation of translational initiation in response to stress : IDA:MGI
- response to endoplasmic reticulum stress : IDA:UniProtKB
- response to manganese-induced endoplasmic reticulum stress : IEA:Ensembl
- stress granule assembly : IMP:ARUK-UCL
- translation : IDA:MGI
|