Peroxiredoxin-2 (Q6PDV3)

Uniprot ID Q6PDV3
Protein Name Peroxiredoxin-2
Gene Name Prdx2
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). .
GO - Molecular function
  • antioxidant activity : ISO:RGD
  • thioredoxin peroxidase activity : ISO:RGD
GO - Biological process
  • activation of MAPK activity : ISO:RGD
  • cell redox homeostasis : IBA:GO_Central
  • cellular response to oxidative stress : ISO:RGD
  • homeostasis of number of cells : ISO:RGD
  • hydrogen peroxide catabolic process : ISO:RGD
  • hydrogen peroxide metabolic process : ISO:RGD
  • leukocyte activation : IBA:GO_Central
  • negative regulation of extrinsic apoptotic signaling pathway : ISO:RGD
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD
  • negative regulation of lipopolysaccharide-mediated signaling pathway : ISO:RGD
  • negative regulation of neuron apoptotic process : IMP:RGD
  • negative regulation of NF-kappaB transcription factor activity : ISO:RGD
  • negative regulation of T cell differentiation : ISO:RGD
  • positive regulation of blood coagulation : ISO:RGD
  • regulation of apoptotic process : ISO:RGD
  • regulation of hydrogen peroxide metabolic process : ISO:RGD
  • removal of superoxide radicals : ISO:RGD
  • respiratory burst involved in inflammatory response : ISO:RGD
  • response to lipopolysaccharide : ISO:RGD
  • response to oxidative stress : IMP:RGD
  • T cell proliferation : ISO:RGD
  • thymus development : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.