Signal peptide(a) |
N |
Secretome P(b) |
|
Function |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). . |
GO - Molecular function |
- antioxidant activity : ISO:RGD
- thioredoxin peroxidase activity : ISO:RGD
|
GO - Biological process |
- activation of MAPK activity : ISO:RGD
- cell redox homeostasis : IBA:GO_Central
- cellular response to oxidative stress : ISO:RGD
- homeostasis of number of cells : ISO:RGD
- hydrogen peroxide catabolic process : ISO:RGD
- hydrogen peroxide metabolic process : ISO:RGD
- leukocyte activation : IBA:GO_Central
- negative regulation of extrinsic apoptotic signaling pathway : ISO:RGD
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD
- negative regulation of lipopolysaccharide-mediated signaling pathway : ISO:RGD
- negative regulation of neuron apoptotic process : IMP:RGD
- negative regulation of NF-kappaB transcription factor activity : ISO:RGD
- negative regulation of T cell differentiation : ISO:RGD
- positive regulation of blood coagulation : ISO:RGD
- regulation of apoptotic process : ISO:RGD
- regulation of hydrogen peroxide metabolic process : ISO:RGD
- removal of superoxide radicals : ISO:RGD
- respiratory burst involved in inflammatory response : ISO:RGD
- response to lipopolysaccharide : ISO:RGD
- response to oxidative stress : IMP:RGD
- T cell proliferation : ISO:RGD
- thymus development : ISO:RGD
|