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Q6P7Q4

Lactoylglutathione lyase (Q6P7Q4)

Uniprot ID Q6P7Q4
Protein Name Lactoylglutathione lyase
Gene Name Glo1
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (8) Interactions
Signal peptide(a) N Secretome P(b)
Function Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). .
GO - Molecular function
  • lactoylglutathione lyase activity : IDA:RGD
  • zinc ion binding : ISO:RGD
GO - Biological process
  • carbohydrate metabolic process : IDA:RGD
  • glutathione metabolic process : IDA:RGD
  • methylglyoxal metabolic process : IDA:RGD
  • negative regulation of apoptotic process : ISS:UniProtKB
  • osteoclast differentiation : ISO:RGD
  • regulation of transcription by RNA polymerase II : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.