Glucose-6-phosphate isomerase (Q6P6V0)

Uniprot ID Q6P6V0
Protein Name Glucose-6-phosphate isomerase
Gene Name Gpi
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:2709006). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). .
GO - Molecular function
  • cytokine activity : IEA:UniProtKB-KW
  • glucose-6-phosphate isomerase activity : IDA:RGD
  • growth factor activity : IEA:UniProtKB-KW
  • intramolecular transferase activity : IMP:RGD
  • monosaccharide binding : IPI:RGD
  • ubiquitin protein ligase binding : ISO:RGD
GO - Biological process
  • aldehyde catabolic process : IMP:RGD
  • carbohydrate metabolic process : IDA:RGD
  • erythrocyte homeostasis : ISO:RGD
  • gluconeogenesis : IBA:GO_Central
  • glucose 6-phosphate metabolic process : IDA:RGD
  • glucose homeostasis : ISO:RGD
  • glycolytic process : ISO:RGD
  • in utero embryonic development : ISO:RGD
  • learning or memory : IEP:RGD
  • mesoderm formation : ISO:RGD
  • methylglyoxal biosynthetic process : IMP:RGD
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : IMP:RGD
  • negative regulation of neuron apoptotic process : IMP:RGD
  • positive regulation of endothelial cell migration : ISO:RGD
  • positive regulation of immunoglobulin secretion : ISO:RGD
  • response to cadmium ion : IEP:RGD
  • response to estradiol : IEP:RGD
  • response to immobilization stress : IEP:RGD
  • response to morphine : IMP:RGD
  • response to muscle stretch : IEP:RGD
  • response to progesterone : IEP:RGD
  • response to testosterone : IEP:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.