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Q6P6T1

Complement C1s subcomponent (Q6P6T1)

Uniprot ID Q6P6T1
Protein Name Complement C1s subcomponent
Gene Name C1s
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) Y Secretome P(b)
Function C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). .
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • identical protein binding : ISO:RGD
  • serine-type endopeptidase activity : ISO:RGD
GO - Biological process
  • complement activation, classical pathway : IEA:UniProtKB-KW
  • glial cell differentiation : IEP:RGD
  • innate immune response : IEA:UniProtKB-KW
  • response to cAMP : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.