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Q6P5E4

UDP-glucose:glycoprotein glucosyltransferase 1 (Q6P5E4)

Uniprot ID Q6P5E4
Protein Name UDP-glucose:glycoprotein glucosyltransferase 1
Gene Name Uggt1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.47
Function Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). .
GO - Molecular function
  • UDP-glucose : ISS:UniProtKB
  • unfolded protein binding : ISS:UniProtKB
GO - Biological process
  • 'de novo' posttranslational protein folding : IBA:GO_Central
  • endoplasmic reticulum unfolded protein response : IBA:GO_Central
  • ER-associated misfolded protein catabolic process : IBA:GO_Central
  • protein N-linked glycosylation via asparagine : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.