| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). . |
| GO - Molecular function |
- actin binding : IDA:RGD
- actin filament binding : IEA:InterPro
- calcium ion binding : ISO:RGD
- myosin II binding : ISO:RGD
|
| GO - Biological process |
- actin filament capping : ISO:RGD
- actin filament polymerization : ISS:UniProtKB
- actin filament reorganization : ISO:RGD
- actin filament severing : IMP:RGD
- actin nucleation : IEA:InterPro
- actin polymerization or depolymerization : IDA:RGD
- aging : IEP:RGD
- amyloid fibril formation : ISO:RGD
- apoptotic process : IDA:RGD
- barbed-end actin filament capping : IEA:InterPro
- cellular response to cadmium ion : IDA:RGD
- cellular response to interferon-gamma : ISO:RGD
- cilium assembly : ISS:UniProtKB
- hepatocyte apoptotic process : ISO:RGD
- negative regulation of viral entry into host cell : ISO:RGD
- oligodendrocyte development : IEP:RGD
- phagocytosis, engulfment : ISO:RGD
- phosphatidylinositol-mediated signaling : IMP:RGD
- positive regulation of actin nucleation : ISO:RGD
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway : ISO:RGD
- positive regulation of gene expression : ISO:RGD
- positive regulation of keratinocyte apoptotic process : ISO:RGD
- positive regulation of protein processing in phagocytic vesicle : ISO:RGD
- protein destabilization : ISO:RGD
- regulation of cell adhesion : IMP:RGD
- regulation of establishment of T cell polarity : ISO:RGD
- regulation of plasma membrane raft polarization : ISO:RGD
- regulation of podosome assembly : ISO:RGD
- regulation of receptor clustering : ISO:RGD
- renal protein absorption : ISO:RGD
- response to ethanol : IEP:RGD
- response to folic acid : IEP:RGD
- sequestering of actin monomers : ISO:RGD
- striated muscle atrophy : ISO:RGD
- tissue regeneration : IEP:RGD
- vesicle-mediated transport : ISO:RGD
- wound healing : IEP:RGD
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