Clathrin heavy chain 1 (Q68FD5)

Uniprot ID Q68FD5
Protein Name Clathrin heavy chain 1
Gene Name Cltc
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.504
Function Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. .
GO - Molecular function
  • ankyrin binding : ISO:MGI
  • clathrin light chain binding : ISO:MGI
  • disordered domain specific binding : ISO:MGI
  • double-stranded RNA binding : ISO:MGI
  • heat shock protein binding : ISO:MGI
  • low-density lipoprotein particle receptor binding : ISO:MGI
  • peptide binding : ISO:MGI
  • protein C-terminus binding : ISO:MGI
  • protein kinase binding : IPI:ParkinsonsUK-UCL
  • structural molecule activity : IEA:InterPro
  • ubiquitin-specific protease binding : ISO:MGI
GO - Biological process
  • autophagy : IEA:UniProtKB-KW
  • cell division : IEA:UniProtKB-KW
  • clathrin coat assembly : ISO:MGI
  • clathrin-dependent endocytosis : ISO:MGI
  • Golgi organization : ISO:MGI
  • intracellular protein transport : IEA:InterPro
  • mitotic cell cycle : ISO:MGI
  • mitotic spindle assembly : ISO:MGI
  • negative regulation of hyaluronan biosynthetic process : ISS:UniProtKB
  • negative regulation of protein localization to plasma membrane : ISO:MGI
  • receptor internalization : ISO:MGI
  • receptor-mediated endocytosis : ISO:MGI
  • regulation of mitotic spindle organization : ISO:MGI
  • retrograde transport, endosome to Golgi : ISO:MGI
  • transcytosis : ISO:MGI
  • transferrin transport : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.