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Q65Z15

Oncostatin-M (Q65Z15)

Uniprot ID Q65Z15
Protein Name Oncostatin-M
Gene Name Osm
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (4) Interactions
Signal peptide(a) Y Secretome P(b) 0.541
Function Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. .
GO - Molecular function
  • cytokine activity : ISO:RGD
  • growth factor activity : ISO:RGD
  • oncostatin-M receptor binding : ISO:RGD
GO - Biological process
  • behavioral response to pain : ISO:RGD
  • immune response : IEA:InterPro
  • negative regulation of hormone secretion : ISO:RGD
  • negative regulation of meiotic nuclear division : ISO:RGD
  • oncostatin-M-mediated signaling pathway : ISO:RGD
  • peripheral nervous system development : ISO:RGD
  • positive regulation of apoptotic signaling pathway : ISO:RGD
  • positive regulation of cell population proliferation : ISO:RGD
  • positive regulation of inflammatory response : ISO:RGD
  • positive regulation of interleukin-17 secretion : ISO:RGD
  • positive regulation of MAPK cascade : ISO:RGD
  • positive regulation of peptidyl-serine phosphorylation : ISO:RGD
  • positive regulation of peptidyl-tyrosine phosphorylation : ISO:RGD
  • positive regulation of phosphatidylinositol 3-kinase signaling : ISO:RGD
  • positive regulation of protein kinase B signaling : ISO:RGD
  • positive regulation of transcription by RNA polymerase II : ISO:RGD
  • positive regulation of tyrosine phosphorylation of STAT protein : ISO:RGD
  • regulation of growth : IEA:UniProtKB-KW
  • response to heat : ISO:RGD
  • tyrosine phosphorylation of STAT protein : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.