| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination (By similarity). Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP. . |
| GO - Molecular function |
- cyclin-dependent protein serine/threonine kinase inhibitor activity : IDA:MGI
- disordered domain specific binding : ISO:MGI
- DNA binding : IEA:UniProtKB-KW
- MDM2/MDM4 family protein binding : IPI:CAFA
- NF-kappaB binding : ISO:MGI
- p53 binding : ISO:MGI
- protein kinase binding : ISO:MGI
- protein N-terminus binding : IPI:MGI
- SUMO transferase activity : ISO:MGI
- transcription factor binding : ISO:MGI
- ubiquitin ligase inhibitor activity : ISO:MGI
- ubiquitin-protein transferase inhibitor activity : IDA:BHF-UCL
|
| GO - Biological process |
- activation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:MGI
- aging : IMP:MGI
- amyloid fibril formation : ISO:MGI
- apoptotic mitochondrial changes : ISO:MGI
- autophagy of mitochondrion : ISO:MGI
- cell aging : IDA:MGI
- cell cycle arrest : IDA:MGI
- cellular response to hydrogen peroxide : IDA:MGI
- cellular senescence : IDA:MGI
- epidermis development : IMP:MGI
- G1/S transition of mitotic cell cycle : ISO:MGI
- glucose homeostasis : IMP:MGI
- mitochondrial depolarization : ISO:MGI
- negative regulation of B cell proliferation : IMP:HGNC-UCL
- negative regulation of cell cycle : IDA:MGI
- negative regulation of cell growth : IMP:BHF-UCL
- negative regulation of cell population proliferation : ISO:MGI
- negative regulation of cell-matrix adhesion : ISO:MGI
- negative regulation of cyclin-dependent protein serine/threonine kinase activity : IDA:MGI
- negative regulation of hepatocyte proliferation : ISO:MGI
- negative regulation of immature T cell proliferation in thymus : IMP:HGNC-UCL
- negative regulation of mammary gland epithelial cell proliferation : IMP:MGI
- negative regulation of NF-kappaB transcription factor activity : ISO:MGI
- negative regulation of phosphorylation : ISO:MGI
- negative regulation of protein binding : IDA:MGI
- negative regulation of protein kinase activity : ISO:MGI
- negative regulation of protein neddylation : ISO:MGI
- negative regulation of proteolysis involved in cellular protein catabolic process : IDA:MGI
- negative regulation of transcription, DNA-templated : ISO:MGI
- negative regulation of ubiquitin protein ligase activity : ISO:MGI
- negative regulation of ubiquitin-dependent protein catabolic process : IDA:MGI
- negative regulation of ubiquitin-protein transferase activity : IDA:BHF-UCL
- positive regulation of apoptotic process : ISS:UniProtKB
- positive regulation of apoptotic process involved in mammary gland involution : IMP:MGI
- positive regulation of cell cycle arrest : ISO:MGI
- positive regulation of cellular senescence : ISO:MGI
- positive regulation of DNA damage response, signal transduction by p53 class mediator : ISO:MGI
- positive regulation of DNA-binding transcription factor activity : IMP:BHF-UCL
- positive regulation of gene expression : ISO:MGI
- positive regulation of protein localization to nucleus : ISO:MGI
- positive regulation of protein sumoylation : ISO:MGI
- positive regulation of signal transduction by p53 class mediator : ISO:MGI
- positive regulation of transcription by RNA polymerase II : ISO:MGI
- positive regulation of transcription, DNA-templated : IMP:BHF-UCL
- protein destabilization : ISO:MGI
- protein K63-linked ubiquitination : ISS:UniProtKB
- protein polyubiquitination : ISS:UniProtKB
- protein stabilization : ISO:MGI
- regulation of apoptotic DNA fragmentation : ISO:MGI
- regulation of cyclin-dependent protein serine/threonine kinase activity : IDA:MGI
- regulation of DNA-binding transcription factor activity : IGI:MGI
- regulation of G2/M transition of mitotic cell cycle : ISO:MGI
- regulation of gene expression : IMP:MGI
- regulation of nucleocytoplasmic transport : IGI:MGI
- regulation of protein export from nucleus : ISO:MGI
- regulation of protein stability : IMP:BHF-UCL
- regulation of protein targeting to mitochondrion : ISO:MGI
- replicative senescence : ISO:MGI
- response to drug : ISO:MGI
- response to organic cyclic compound : ISO:MGI
- response to organonitrogen compound : ISO:MGI
- rRNA processing : IEA:UniProtKB-KW
- rRNA transcription : IGI:MGI
- senescence-associated heterochromatin focus assembly : ISO:MGI
- somatic stem cell division : IMP:HGNC-UCL
- somatic stem cell population maintenance : IGI:MGI
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