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Q642G2

Sclerostin domain-containing protein 1 (Q642G2)

Uniprot ID Q642G2
Protein Name Sclerostin domain-containing protein 1
Gene Name Sostdc1
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (4) Interactions
Signal peptide(a) Y Secretome P(b)
Function Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. .
GO - Molecular function
  • BMP binding : ISO:RGD
  • BMP receptor activity : ISO:RGD
GO - Biological process
  • embryo implantation : NAS:RGD
  • hair follicle morphogenesis : ISO:RGD
  • mammary gland bud morphogenesis : ISO:RGD
  • negative regulation of BMP signaling pathway : ISO:RGD
  • negative regulation of canonical Wnt signaling pathway : ISO:RGD
  • negative regulation of cell fate commitment : ISO:RGD
  • negative regulation of determination of dorsal identity : ISO:RGD
  • negative regulation of myoblast differentiation : ISO:RGD
  • negative regulation of Wnt signaling pathway : ISO:RGD
  • odontogenesis of dentin-containing tooth : ISO:RGD
  • pattern specification process : ISO:RGD
  • Wnt signaling pathway : IEA:UniProtKB-KW
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.