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Q64194

Lysosomal acid lipase/cholesteryl ester hydrolase (Q64194)

Uniprot ID Q64194
Protein Name Lysosomal acid lipase/cholesteryl ester hydrolase
Gene Name Lipa
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) Y Secretome P(b)
Function Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation (By similarity). .
GO - Molecular function
  • lipase activity : IDA:RGD
  • sterol esterase activity : IDA:RGD
GO - Biological process
  • cell morphogenesis : ISO:RGD
  • cell population proliferation : ISO:RGD
  • cytokine production : ISO:RGD
  • fatty acid metabolic process : IDA:RGD
  • homeostasis of number of cells within a tissue : ISO:RGD
  • inflammatory response : ISO:RGD
  • lipid catabolic process : IEA:UniProtKB-KW
  • lung development : ISO:RGD
  • sterol metabolic process : IDA:RGD
  • tissue remodeling : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.