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Q640N1

Adipocyte enhancer-binding protein 1 (Q640N1)

Uniprot ID Q640N1
Protein Name Adipocyte enhancer-binding protein 1
Gene Name Aebp1
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.194
Function Isoform 2 may positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. Isoform 2 may also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. .
GO - Molecular function
  • calmodulin binding : IEA:UniProtKB-KW
  • carboxypeptidase activity : IDA:MGI
  • metallocarboxypeptidase activity : IBA:GO_Central
  • RNA polymerase II regulatory region sequence-specific DNA binding : ISO:MGI
  • serine-type carboxypeptidase activity : IBA:GO_Central
  • transcription corepressor activity : IDA:MGI
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding : ISO:MGI
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • negative regulation of transcription by RNA polymerase II : ISO:MGI
  • peptide metabolic process : IBA:GO_Central
  • protein processing : IBA:GO_Central
  • regulation of transcription, DNA-templated : IDA:MGI
  • transcription, DNA-templated : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.