| Signal peptide(a) |
N |
Secretome P(b) |
0.625 |
| Function |
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. . |
| GO - Molecular function |
- cytoskeletal protein binding : ISO:MGI
- enzyme binding : ISO:MGI
- ephrin receptor binding : IPI:UniProtKB
- insulin-like growth factor receptor binding : ISO:MGI
- phosphotyrosine residue binding : ISO:MGI
- protein binding, bridging : ISO:MGI
- protein domain specific binding : ISO:MGI
- protein phosphorylated amino acid binding : IDA:MGI
- protein self-association : ISO:MGI
- protein tyrosine kinase binding : ISO:MGI
- scaffold protein binding : ISO:MGI
- SH2 domain binding : IPI:CAFA
- SH3 domain binding : ISO:MGI
- SH3/SH2 adaptor activity : IPI:BHF-UCL
|
| GO - Biological process |
- cellular response to endothelin : ISO:MGI
- cellular response to insulin-like growth factor stimulus : ISO:MGI
- cellular response to nerve growth factor stimulus : ISO:MGI
- cellular response to nitric oxide : ISO:MGI
- cellular response to transforming growth factor beta stimulus : ISO:MGI
- ephrin receptor signaling pathway : ISS:UniProtKB
- negative regulation of cell motility : ISO:MGI
- negative regulation of natural killer cell mediated cytotoxicity : ISO:MGI
- negative regulation of wound healing : ISO:MGI
- positive regulation of cell growth : ISO:MGI
- positive regulation of smooth muscle cell migration : ISO:MGI
- positive regulation of substrate adhesion-dependent cell spreading : ISS:UniProtKB
- regulation of actin cytoskeleton organization : IGI:MGI
- regulation of cell shape : ISO:MGI
- regulation of GTPase activity : ISS:UniProtKB
- regulation of protein binding : ISO:MGI
- regulation of Rac protein signal transduction : ISO:MGI
- regulation of signal transduction : ISO:MGI
- response to cholecystokinin : ISO:MGI
- response to hepatocyte growth factor : ISO:MGI
- response to hydrogen peroxide : ISO:MGI
- response to peptide : ISO:MGI
- response to yeast : IEA:Ensembl
- SH2 domain-mediated complex assembly : ISO:MGI
|