Interleukin-1 beta (Q63264)

Uniprot ID	Q63264
Protein Name	Interleukin-1 beta
Gene Name	Il1b
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	N	Secretome P^(b)
Function	Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. .
GO - Molecular function	cytokine activity : IDA:RGD integrin binding : ISS:UniProtKB interleukin-1 receptor binding : IEA:InterPro protein domain specific binding : ISO:RGD
GO - Biological process	activation of MAPK activity : ISO:RGD acute inflammatory response : IEP:RGD astrocyte activation : ISO:RGD cellular response to antibiotic : IEP:RGD cellular response to drug : ISO:RGD cellular response to fatty acid : IEP:RGD cellular response to glucose stimulus : IEP:RGD cellular response to lipid : IEP:RGD cellular response to lipopolysaccharide : IEP:RGD cellular response to mechanical stimulus : ISO:RGD cellular response to organic cyclic compound : ISO:RGD cellular response to organic substance : ISO:RGD chronic inflammatory response to antigenic stimulus : IEP:RGD cytokine-mediated signaling pathway : ISO:RGD ectopic germ cell programmed cell death : ISO:RGD extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD fever generation : IEP:RGD hyaluronan biosynthetic process : ISO:RGD inflammatory response : ISO:RGD inflammatory response to antigenic stimulus : IBA:GO_Central interleukin-1 beta production : ISO:RGD interleukin-6 production : ISO:RGD learning or memory : IEP:RGD leukocyte migration : ISO:RGD lipopolysaccharide-mediated signaling pathway : ISO:RGD MAPK cascade : ISO:RGD memory : IMP:RGD monocyte aggregation : ISO:RGD negative regulation of adiponectin secretion : ISO:RGD negative regulation of branching morphogenesis of a nerve : IDA:RGD negative regulation of cell population proliferation : ISO:RGD negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD negative regulation of gap junction assembly : ISO:RGD negative regulation of gene expression : IDA:RGD negative regulation of glucose transmembrane transport : ISO:RGD negative regulation of glutamate secretion : IMP:RGD negative regulation of insulin receptor signaling pathway : ISO:RGD negative regulation of lipid catabolic process : ISO:RGD negative regulation of lipid metabolic process : ISO:RGD negative regulation of MAP kinase activity : ISO:RGD negative regulation of neural precursor cell proliferation : IDA:RGD negative regulation of neurogenesis : IDA:RGD negative regulation of neuron differentiation : IDA:RGD negative regulation of synaptic transmission : ISO:RGD negative regulation of transcription by RNA polymerase II : IDA:RGD neutrophil chemotaxis : ISO:RGD ovulation : IEP:RGD positive regulation of angiogenesis : ISO:RGD positive regulation of apoptotic process : IMP:RGD positive regulation of astrocyte differentiation : IDA:RGD positive regulation of calcidiol 1-monooxygenase activity : ISO:RGD positive regulation of cell death : IDA:RGD positive regulation of cell division : IEA:UniProtKB-KW positive regulation of cell migration : ISO:RGD positive regulation of cell population proliferation : ISO:RGD positive regulation of chemokine biosynthetic process : ISO:RGD positive regulation of complement activation : ISO:RGD positive regulation of cytosolic calcium ion concentration : IDA:RGD positive regulation of DNA-binding transcription factor activity : ISO:RGD positive regulation of epithelial to mesenchymal transition : ISO:RGD positive regulation of ERK1 and ERK2 cascade : IDA:RGD positive regulation of fever generation : ISO:RGD positive regulation of gene expression : IDA:RGD positive regulation of glial cell differentiation : IDA:RGD positive regulation of glial cell proliferation : ISO:RGD positive regulation of granulocyte macrophage colony-stimulating factor production : ISO:RGD positive regulation of heterotypic cell-cell adhesion : ISO:RGD positive regulation of I-kappaB kinase/NF-kappaB signaling : IDA:RGD positive regulation of immature T cell proliferation in thymus : IDA:RGD positive regulation of inflammatory response : ISO:RGD positive regulation of interferon-gamma production : ISS:UniProtKB positive regulation of interleukin-2 biosynthetic process : ISO:RGD positive regulation of interleukin-6 biosynthetic process : ISO:RGD positive regulation of interleukin-6 production : IDA:RGD positive regulation of interleukin-6 secretion : ISO:RGD positive regulation of interleukin-8 production : ISO:RGD positive regulation of JNK cascade : IDA:RGD positive regulation of JUN kinase activity : IMP:RGD positive regulation of lipid catabolic process : ISO:RGD positive regulation of membrane protein ectodomain proteolysis : ISO:RGD positive regulation of mitotic nuclear division : ISO:RGD positive regulation of monocyte chemotactic protein-1 production : ISO:RGD positive regulation of myosin light chain kinase activity : ISO:RGD positive regulation of neuron apoptotic process : IMP:RGD positive regulation of neutrophil chemotaxis : IMP:RGD positive regulation of NF-kappaB transcription factor activity : ISO:RGD positive regulation of NIK/NF-kappaB signaling : ISO:RGD positive regulation of nitric oxide biosynthetic process : ISO:RGD positive regulation of p38MAPK cascade : ISO:RGD positive regulation of phagocytosis : ISO:RGD positive regulation of prostaglandin biosynthetic process : ISO:RGD positive regulation of prostaglandin secretion : ISO:RGD positive regulation of protein phosphorylation : ISO:RGD positive regulation of RNA biosynthetic process : ISO:RGD positive regulation of stress-activated MAPK cascade : IDA:RGD positive regulation of T cell proliferation : ISO:RGD positive regulation of T-helper 1 cell cytokine production : ISS:UniProtKB positive regulation of transcription by RNA polymerase II : IDA:RGD positive regulation of transcription, DNA-templated : ISO:RGD positive regulation of vascular endothelial growth factor production : ISO:RGD protein kinase B signaling : ISO:RGD regulation of defense response to virus by host : ISO:RGD regulation of ERK1 and ERK2 cascade : ISO:RGD regulation of establishment of endothelial barrier : ISO:RGD regulation of I-kappaB kinase/NF-kappaB signaling : ISO:RGD regulation of insulin secretion : ISO:RGD regulation of neurogenesis : IGI:ARUK-UCL regulation of nitric-oxide synthase activity : ISO:RGD response to ATP : ISO:RGD response to carbohydrate : ISO:RGD response to dexamethasone : IEP:RGD response to drug : IEP:RGD response to estradiol : IEP:RGD response to ethanol : IEP:RGD response to gamma radiation : IEP:RGD response to glucocorticoid : IEP:RGD response to heat : IEP:RGD response to hypoxia : IEP:RGD response to immobilization stress : IEP:RGD response to interleukin-1 : ISO:RGD response to L-ascorbic acid : IEP:RGD response to lipopolysaccharide : IEP:RGD response to morphine : IEP:RGD response to nutrient : IEP:RGD response to organic cyclic compound : IEP:RGD response to organonitrogen compound : IEP:RGD response to ozone : IEP:RGD response to peptide hormone : IEP:RGD response to stilbenoid : IEP:RGD response to vitamin D : IEP:RGD sequestering of triglyceride : ISO:RGD social behavior : IMP:RGD wound healing : IEP:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}