Transferrin receptor protein 1 (Q62351)

Uniprot ID Q62351
Protein Name Transferrin receptor protein 1
Gene Name Tfrc
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.653
Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Upon stimulation, positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). .
GO - Molecular function
  • chaperone binding : ISO:MGI
  • double-stranded RNA binding : ISO:MGI
  • Hsp70 protein binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • iron ion transmembrane transporter activity : TAS:MGI
  • protein homodimerization activity : ISO:MGI
  • transferrin receptor activity : ISS:UniProtKB
  • transferrin transmembrane transporter activity : IEA:InterPro
GO - Biological process
  • cellular iron ion homeostasis : IMP:MGI
  • cellular response to drug : ISO:MGI
  • cellular response to extracellular stimulus : TAS:BHF-UCL
  • cellular response to iron ion : TAS:BHF-UCL
  • cellular response to leukemia inhibitory factor : IEP:MGI
  • iron ion import : ISO:MGI
  • osteoclast differentiation : IMP:DFLAT
  • positive regulation of B cell proliferation : IDA:UniProtKB
  • positive regulation of bone resorption : IDA:DFLAT
  • positive regulation of isotype switching : ISS:UniProtKB
  • positive regulation of T cell proliferation : IDA:UniProtKB
  • receptor internalization : ISS:UniProtKB
  • transferrin transport : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.