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Q62270

Tyrosine-protein kinase Srms (Q62270)

Uniprot ID Q62270
Protein Name Tyrosine-protein kinase Srms
Gene Name Srms
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • non-membrane spanning protein tyrosine kinase activity : IBA:GO_Central
  • protein tyrosine kinase activity : ISS:UniProtKB
  • signaling receptor binding : IBA:GO_Central
GO - Biological process
  • cell differentiation : IBA:GO_Central
  • innate immune response : IBA:GO_Central
  • peptidyl-tyrosine autophosphorylation : ISS:UniProtKB
  • peptidyl-tyrosine phosphorylation : ISO:MGI
  • regulation of cell proliferation : IBA:GO_Central
  • transmembrane receptor protein tyrosine kinase signaling pathway : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.