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Q61990

Poly(rC)-binding protein 2 (Q61990)

Uniprot ID Q61990
Protein Name Poly(rC)-binding protein 2
Gene Name Pcbp2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.653
Function Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation (By similarity). .
GO - Molecular function
  • C-rich single-stranded DNA binding : IDA:MGI
  • DNA binding : IDA:MGI
  • enzyme binding : ISO:MGI
  • RNA binding : ISO:MGI
  • ubiquitin protein ligase binding : ISO:MGI
GO - Biological process
  • defense response to virus : IEA:UniProtKB-KW
  • innate immune response : IEA:UniProtKB-KW
  • IRES-dependent viral translational initiation : ISO:MGI
  • negative regulation of defense response to virus : ISS:UniProtKB
  • proteasome-mediated ubiquitin-dependent protein catabolic process : ISS:UniProtKB
  • viral RNA genome replication : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.