Pregnancy zone protein (Q61838)

Uniprot ID Q61838
Protein Name Pregnancy zone protein
Gene Name Pzp
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.535
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
GO - Molecular function
  • brain-derived neurotrophic factor binding : ISO:MGI
  • endopeptidase inhibitor activity : IDA:MGI
  • nerve growth factor binding : ISO:MGI
  • protein-containing complex binding : ISO:MGI
  • serine-type endopeptidase inhibitor activity : IEA:UniProtKB-KW
GO - Biological process
  • embryo implantation : IGI:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.