| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA. . |
| GO - Molecular function |
- RNA binding : IEA:UniProtKB-KW
|
| GO - Biological process |
- apoptotic process : IEA:UniProtKB-KW
- BMP signaling pathway : ISO:MGI
- cell aging : ISS:UniProtKB
- cellular response to lipopolysaccharide : IMP:BHF-UCL
- epithelial to mesenchymal transition involved in cardiac fibroblast development : ISO:MGI
- negative regulation of apoptotic process : ISO:MGI
- negative regulation of cytokine production involved in inflammatory response : IMP:BHF-UCL
- negative regulation of JUN kinase activity : ISS:UniProtKB
- negative regulation of myofibroblast differentiation : ISO:MGI
- negative regulation of transcription, DNA-templated : ISS:UniProtKB
- negative regulation of vascular smooth muscle cell differentiation : ISO:MGI
- negative regulation of vascular smooth muscle cell proliferation : ISO:MGI
- positive regulation of endothelial cell apoptotic process : ISO:MGI
- positive regulation of inflammatory response : IMP:BHF-UCL
- positive regulation of NIK/NF-kappaB signaling : ISO:MGI
- positive regulation of smooth muscle cell apoptotic process : ISO:MGI
- positive regulation of vascular associated smooth muscle cell apoptotic process : ISO:MGI
- regulation of protein metabolic process : ISO:MGI
|