Signal peptide(a) |
Y |
Secretome P(b) |
0.675 |
Function |
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:9144073). Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24380872). . |
GO - Molecular function |
- lipopeptide binding : ISO:MGI
- lipopolysaccharide binding : IDA:MGI
- lipoteichoic acid binding : ISO:MGI
- signaling receptor binding : IDA:BHF-UCL
|
GO - Biological process |
- acute-phase response : IMP:BHF-UCL
- cellular response to lipopolysaccharide : IMP:UniProtKB
- cellular response to lipoteichoic acid : ISO:MGI
- defense response to Gram-negative bacterium : IMP:BHF-UCL
- defense response to Gram-positive bacterium : IMP:BHF-UCL
- detection of molecule of bacterial origin : ISO:MGI
- innate immune response : IMP:BHF-UCL
- leukocyte chemotaxis involved in inflammatory response : IMP:MGI
- lipopolysaccharide transport : ISO:MGI
- lipopolysaccharide-mediated signaling pathway : ISO:MGI
- macromolecule localization : ISO:MGI
- macrophage activation involved in immune response : IDA:BHF-UCL
- negative regulation of growth of symbiont in host : IMP:MGI
- negative regulation of tumor necrosis factor production : ISO:MGI
- opsonization : IC:BHF-UCL
- positive regulation of chemokine production : IMP:MGI
- positive regulation of cytolysis : ISO:MGI
- positive regulation of interleukin-6 production : ISO:MGI
- positive regulation of interleukin-8 production : ISO:MGI
- positive regulation of macrophage activation : ISO:MGI
- positive regulation of neutrophil chemotaxis : IMP:MGI
- positive regulation of phagocytosis, engulfment : ISO:MGI
- positive regulation of respiratory burst involved in inflammatory response : IMP:BHF-UCL
- positive regulation of toll-like receptor 4 signaling pathway : ISO:MGI
- positive regulation of tumor necrosis factor biosynthetic process : IMP:MGI
- positive regulation of tumor necrosis factor production : IDA:BHF-UCL
- regulation of membrane permeability : ISO:MGI
- response to lipopolysaccharide : IMP:BHF-UCL
|