Lipopolysaccharide-binding protein (Q61805)

Uniprot ID Q61805
Protein Name Lipopolysaccharide-binding protein
Gene Name Lbp
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.675
Function Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:9144073). Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24380872). .
GO - Molecular function
  • lipopeptide binding : ISO:MGI
  • lipopolysaccharide binding : IDA:MGI
  • lipoteichoic acid binding : ISO:MGI
  • signaling receptor binding : IDA:BHF-UCL
GO - Biological process
  • acute-phase response : IMP:BHF-UCL
  • cellular response to lipopolysaccharide : IMP:UniProtKB
  • cellular response to lipoteichoic acid : ISO:MGI
  • defense response to Gram-negative bacterium : IMP:BHF-UCL
  • defense response to Gram-positive bacterium : IMP:BHF-UCL
  • detection of molecule of bacterial origin : ISO:MGI
  • innate immune response : IMP:BHF-UCL
  • leukocyte chemotaxis involved in inflammatory response : IMP:MGI
  • lipopolysaccharide transport : ISO:MGI
  • lipopolysaccharide-mediated signaling pathway : ISO:MGI
  • macromolecule localization : ISO:MGI
  • macrophage activation involved in immune response : IDA:BHF-UCL
  • negative regulation of growth of symbiont in host : IMP:MGI
  • negative regulation of tumor necrosis factor production : ISO:MGI
  • opsonization : IC:BHF-UCL
  • positive regulation of chemokine production : IMP:MGI
  • positive regulation of cytolysis : ISO:MGI
  • positive regulation of interleukin-6 production : ISO:MGI
  • positive regulation of interleukin-8 production : ISO:MGI
  • positive regulation of macrophage activation : ISO:MGI
  • positive regulation of neutrophil chemotaxis : IMP:MGI
  • positive regulation of phagocytosis, engulfment : ISO:MGI
  • positive regulation of respiratory burst involved in inflammatory response : IMP:BHF-UCL
  • positive regulation of toll-like receptor 4 signaling pathway : ISO:MGI
  • positive regulation of tumor necrosis factor biosynthetic process : IMP:MGI
  • positive regulation of tumor necrosis factor production : IDA:BHF-UCL
  • regulation of membrane permeability : ISO:MGI
  • response to lipopolysaccharide : IMP:BHF-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.