| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex. . |
| GO - Molecular function |
- glutamate receptor activity : IBA:GO_Central
- identical protein binding : ISO:MGI
- ionotropic glutamate receptor activity : IEA:InterPro
- PDZ domain binding : IPI:BHF-UCL
- scaffold protein binding : IPI:BHF-UCL
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential : IBA:GO_Central
|
| GO - Biological process |
- cellular protein localization : IDA:BHF-UCL
- cerebellar granule cell differentiation : IGI:BHF-UCL
- excitatory postsynaptic potential : IMP:MGI
- excitatory synapse assembly : ISO:MGI
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : IGI:BHF-UCL
- modulation of chemical synaptic transmission : IBA:GO_Central
- positive regulation of long-term synaptic depression : ISO:MGI
- positive regulation of synapse assembly : ISO:MGI
- prepulse inhibition : IMP:MGI
- regulation of neuron apoptotic process : IMP:MGI
- regulation of neuron projection development : IMP:MGI
- regulation of postsynaptic density assembly : IDA:SynGO
- regulation of presynapse assembly : ISO:MGI
- synaptic transmission, glutamatergic : IMP:MGI
|