Glutamate receptor ionotropic, delta-2 (Q61625)

Uniprot ID Q61625
Protein Name Glutamate receptor ionotropic, delta-2
Gene Name Grid2
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b)
Function Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex. .
GO - Molecular function
  • glutamate receptor activity : IBA:GO_Central
  • identical protein binding : ISO:MGI
  • ionotropic glutamate receptor activity : IEA:InterPro
  • PDZ domain binding : IPI:BHF-UCL
  • scaffold protein binding : IPI:BHF-UCL
  • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential : IBA:GO_Central
GO - Biological process
  • cellular protein localization : IDA:BHF-UCL
  • cerebellar granule cell differentiation : IGI:BHF-UCL
  • excitatory postsynaptic potential : IMP:MGI
  • excitatory synapse assembly : ISO:MGI
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : IGI:BHF-UCL
  • modulation of chemical synaptic transmission : IBA:GO_Central
  • positive regulation of long-term synaptic depression : ISO:MGI
  • positive regulation of synapse assembly : ISO:MGI
  • prepulse inhibition : IMP:MGI
  • regulation of neuron apoptotic process : IMP:MGI
  • regulation of neuron projection development : IMP:MGI
  • regulation of postsynaptic density assembly : IDA:SynGO
  • regulation of presynapse assembly : ISO:MGI
  • synaptic transmission, glutamatergic : IMP:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.