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Q61553

Fascin (Q61553)

Uniprot ID Q61553
Protein Name Fascin
Gene Name Fscn1
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.484
Function Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (By similarity). .
GO - Molecular function
  • actin binding : IDA:MGI
  • actin filament binding : IMP:MGI
  • cadherin binding : ISO:MGI
  • drug binding : IDA:UniProtKB
  • protein binding, bridging : IEA:InterPro
GO - Biological process
  • actin cytoskeleton organization : ISO:MGI
  • actin filament bundle assembly : IDA:MGI
  • anatomical structure morphogenesis : IBA:GO_Central
  • cell migration : IMP:UniProtKB
  • cell motility : ISS:UniProtKB
  • cell-cell junction assembly : ISS:UniProtKB
  • establishment of apical/basal cell polarity : ISS:UniProtKB
  • establishment or maintenance of cell polarity : IBA:GO_Central
  • microspike assembly : ISS:UniProtKB
  • positive regulation of extracellular matrix disassembly : ISS:UniProtKB
  • positive regulation of filopodium assembly : ISS:UniProtKB
  • positive regulation of lamellipodium assembly : ISS:UniProtKB
  • positive regulation of podosome assembly : ISS:UniProtKB
  • regulation of actin cytoskeleton organization : ISS:UniProtKB
  • regulation of microvillus assembly : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.