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Q61453

Interleukin-17A (Q61453)

Uniprot ID Q61453
Protein Name Interleukin-17A
Gene Name Il17a
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. .
GO - Molecular function
  • cytokine activity : IEA:UniProtKB-KW
GO - Biological process
  • cellular response to glucocorticoid stimulus : IMP:RGD
  • cellular response to interleukin-1 : ISO:RGD
  • defense response to fungus : ISO:RGD
  • fibroblast activation : ISO:RGD
  • granulocyte migration : ISO:RGD
  • inflammatory response : IEA:InterPro
  • positive regulation of cytokine production involved in inflammatory response : ISO:RGD
  • positive regulation of interleukin-23 production : ISO:RGD
  • positive regulation of interleukin-6 secretion : ISO:RGD
  • positive regulation of necrotic cell death : IDA:RGD
  • positive regulation of osteoclast differentiation : ISO:RGD
  • positive regulation of transcription by RNA polymerase II : IDA:RGD
  • response to amino acid : IEP:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.