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Q61233

Plastin-2 (Q61233)

Uniprot ID Q61233
Protein Name Plastin-2
Gene Name Lcp1
Species Mus musculus (Mouse)
Basic Information Experiments (4) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.618
Function Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. .
GO - Molecular function
  • actin filament binding : IDA:MGI
  • calcium ion binding : IEA:InterPro
  • GTPase binding : ISO:MGI
  • identical protein binding : IPI:MGI
  • integrin binding : ISO:MGI
GO - Biological process
  • actin crosslink formation : IBA:GO_Central
  • actin filament bundle assembly : IDA:MGI
  • actin filament network formation : IBA:GO_Central
  • animal organ regeneration : IEA:Ensembl
  • cell migration : ISO:MGI
  • extracellular matrix disassembly : ISO:MGI
  • positive regulation of podosome assembly : ISO:MGI
  • protein kinase A signaling : ISO:MGI
  • regulation of intracellular protein transport : ISS:UniProtKB
  • response to wounding : ISO:MGI
  • T cell activation involved in immune response : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.