| Signal peptide(a) |
N |
Secretome P(b) |
0.838 |
| Function |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). . |
| GO - Molecular function |
- antioxidant activity : ISO:MGI
- peroxidase activity : TAS:MGI
- selenium binding : TAS:MGI
- thioredoxin peroxidase activity : ISS:MGI
|
| GO - Biological process |
- activation of MAPK activity : IMP:MGI
- cell redox homeostasis : IEA:InterPro
- cellular response to oxidative stress : ISO:MGI
- homeostasis of number of cells : IMP:MGI
- hydrogen peroxide catabolic process : IMP:MGI
- hydrogen peroxide metabolic process : IMP:MGI
- negative regulation of extrinsic apoptotic signaling pathway : IMP:MGI
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : IDA:MGI
- negative regulation of lipopolysaccharide-mediated signaling pathway : IMP:MGI
- negative regulation of neuron apoptotic process : ISO:MGI
- negative regulation of NF-kappaB transcription factor activity : IMP:MGI
- negative regulation of reactive oxygen species metabolic process : IMP:MGI
- negative regulation of T cell differentiation : IMP:MGI
- positive regulation of blood coagulation : IMP:BHF-UCL
- regulation of apoptotic process : ISO:MGI
- regulation of hydrogen peroxide metabolic process : IMP:MGI
- removal of superoxide radicals : IMP:BHF-UCL
- respiratory burst involved in inflammatory response : IMP:MGI
- response to lipopolysaccharide : IMP:MGI
- response to oxidative stress : ISO:MGI
- T cell proliferation : IMP:MGI
- thymus development : IMP:MGI
|