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Q61147

Ceruloplasmin (Q61147)

Uniprot ID Q61147
Protein Name Ceruloplasmin
Gene Name Cp
Species Mus musculus (Mouse)
Basic Information Experiments (5) Disease (15) Interactions
Signal peptide(a) Y Secretome P(b) 0.599
Function Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). .
GO - Molecular function
  • chaperone binding : ISO:MGI
  • copper ion binding : IDA:MGI
  • ferroxidase activity : IDA:MGI
GO - Biological process
  • cellular iron ion homeostasis : IEA:InterPro
  • copper ion transport : IEA:UniProtKB-KW
  • response to copper ion : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.