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Q61081

Hsp90 co-chaperone Cdc37 (Q61081)

Uniprot ID Q61081
Protein Name Hsp90 co-chaperone Cdc37
Gene Name Cdc37
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.455
Function Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity (By similarity). .
GO - Molecular function
  • chaperone binding : ISO:MGI
  • heat shock protein binding : ISO:MGI
  • Hsp90 protein binding : IDA:MGI
  • kinase binding : IPI:ParkinsonsUK-UCL
  • mitogen-activated protein kinase kinase kinase binding : ISO:MGI
  • protein C-terminus binding : ISO:MGI
  • protein kinase B binding : ISO:MGI
  • protein kinase binding : ISO:MGI
  • protein tyrosine kinase activity : ISO:MGI
  • scaffold protein binding : ISO:MGI
  • unfolded protein binding : IBA:GO_Central
GO - Biological process
  • positive regulation of mitophagy in response to mitochondrial depolarization : IDA:ParkinsonsUK-UCL
  • posttranscriptional regulation of gene expression : IDA:ParkinsonsUK-UCL
  • protein folding : IBA:GO_Central
  • protein stabilization : IBA:GO_Central
  • regulation of interferon-gamma-mediated signaling pathway : ISO:MGI
  • regulation of protein kinase activity : IDA:ParkinsonsUK-UCL
  • regulation of type I interferon-mediated signaling pathway : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.