Platelet-activating factor acetylhydrolase (Q60963)

Uniprot ID Q60963
Protein Name Platelet-activating factor acetylhydrolase
Gene Name Pla2g7
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.761
Function Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
GO - Molecular function
  • 1-alkyl-2-acetylglycerophosphocholine esterase activity : ISO:MGI
  • calcium-independent phospholipase A2 activity : ISO:MGI
  • phospholipid binding : ISO:MGI
GO - Biological process
  • inflammatory response : TAS:MGI
  • lipid catabolic process : IEA:UniProtKB-KW
  • lipid oxidation : ISO:MGI
  • low-density lipoprotein particle remodeling : ISO:MGI
  • plasma lipoprotein particle oxidation : ISO:MGI
  • platelet activating factor metabolic process : ISO:MGI
  • positive regulation of monocyte chemotaxis : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.