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Q60876

Eukaryotic translation initiation factor 4E-binding protein 1 (Q60876)

Uniprot ID Q60876
Protein Name Eukaryotic translation initiation factor 4E-binding protein 1
Gene Name Eif4ebp1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (7) Interactions
Signal peptide(a) N Secretome P(b) 0.91
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7629182). .
GO - Molecular function
  • eukaryotic initiation factor 4E binding : IPI:MGI
  • protein phosphatase 2A binding : ISO:MGI
  • translation initiation factor binding : ISO:MGI
  • translation repressor activity : ISS:UniProtKB
GO - Biological process
  • cellular response to dexamethasone stimulus : IDA:MGI
  • cellular response to hypoxia : ISO:MGI
  • G1/S transition of mitotic cell cycle : ISO:MGI
  • insulin receptor signaling pathway : IDA:MGI
  • IRES-dependent translational initiation of linear mRNA : IDA:ParkinsonsUK-UCL
  • lung development : IEA:Ensembl
  • negative regulation of protein complex assembly : ISO:MGI
  • negative regulation of translational initiation : IDA:MGI
  • positive regulation of mitotic cell cycle : ISO:MGI
  • regulation of translational initiation : TAS:MGI
  • response to amino acid starvation : ISO:MGI
  • response to ethanol : IEA:Ensembl
  • response to ischemia : IEA:Ensembl
  • TOR signaling : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.