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Q5SUR0

Phosphoribosylformylglycinamidine synthase (Q5SUR0)

Uniprot ID Q5SUR0
Protein Name Phosphoribosylformylglycinamidine synthase
Gene Name Pfas
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.547
Function Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • metal ion binding : IEA:UniProtKB-KW
  • phosphoribosylformylglycinamidine synthase activity : ISO:MGI
GO - Biological process
  • 'de novo' IMP biosynthetic process : IEA:UniProtKB-UniPathway
  • anterior head development : IMP:MGI
  • glutamine metabolic process : ISO:MGI
  • response to drug : IEA:Ensembl
  • ribonucleoside monophosphate biosynthetic process : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.