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Q5FVH2

5'-3' exonuclease PLD3 (Q5FVH2)

Uniprot ID Q5FVH2
Protein Name 5'-3' exonuclease PLD3
Gene Name Pld3
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) N Secretome P(b)
Function 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). .
GO - Molecular function
  • single-stranded DNA 5'-3' exodeoxyribonuclease activity : ISS:UniProtKB
GO - Biological process
  • immune system process : IEA:UniProtKB-KW
  • inflammatory response : IEA:UniProtKB-KW
  • myotube differentiation : ISS:UniProtKB
  • regulation of cytokine production involved in inflammatory response : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.