| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin-and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). . |
| GO - Molecular function |
- fibronectin binding : IDA:RGD
- growth factor activity : IDA:RGD
- heparin binding : ISO:RGD
- insulin-like growth factor binding : IEA:InterPro
- integrin binding : ISO:RGD
- protein C-terminus binding : ISO:RGD
|
| GO - Biological process |
- aging : IEP:RGD
- angiogenesis : ISO:RGD
- cartilage condensation : ISO:RGD
- cell adhesion : IBA:GO_Central
- cell differentiation : ISO:RGD
- cell migration : ISO:RGD
- cell-matrix adhesion : ISO:RGD
- chondrocyte proliferation : ISO:RGD
- connective tissue development : ISO:RGD
- cytosolic calcium ion transport : IMP:RGD
- DNA biosynthetic process : IEA:UniProtKB-KW
- extracellular matrix constituent secretion : IMP:RGD
- fibroblast growth factor receptor signaling pathway : ISO:RGD
- integrin-mediated signaling pathway : ISO:RGD
- intracellular signal transduction : IDA:RGD
- lung development : IEP:RGD
- negative regulation of cell death : IMP:RGD
- negative regulation of gene expression : ISO:RGD
- ossification : ISO:RGD
- positive regulation of cardiac muscle contraction : IMP:RGD
- positive regulation of cell activation : IMP:RGD
- positive regulation of cell death : IMP:RGD
- positive regulation of cell differentiation : ISO:RGD
- positive regulation of cell population proliferation : IMP:RGD
- positive regulation of collagen biosynthetic process : IMP:RGD
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process : IMP:RGD
- positive regulation of ERK1 and ERK2 cascade : ISO:RGD
- positive regulation of G0 to G1 transition : IMP:RGD
- positive regulation of gene expression : IMP:RGD
- positive regulation of JNK cascade : ISO:RGD
- positive regulation of protein phosphorylation : IMP:RGD
- positive regulation of stress fiber assembly : ISO:RGD
- reactive oxygen species metabolic process : ISO:RGD
- regulation of chondrocyte differentiation : ISO:RGD
- response to amino acid : IEP:RGD
- response to anoxia : IEP:RGD
- response to estradiol : IEP:RGD
- response to fatty acid : IEP:RGD
- response to glucose : IEP:RGD
- response to mineralocorticoid : IEP:RGD
- response to organic cyclic compound : IEP:RGD
- response to peptide hormone : IEP:RGD
- signal transduction : IBA:GO_Central
- tissue homeostasis : ISO:RGD
|