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Q3USB7

Inactive phospholipase C-like protein 1 (Q3USB7)

Uniprot ID Q3USB7
Protein Name Inactive phospholipase C-like protein 1
Gene Name Plcl1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b) 0.351
Function Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Acts as a inhibitor of PPP1C (By similarity). Involved in the assembly and/or the trafficking of gamma-2 subunit-containing GABA A receptors. .
GO - Molecular function
  • GABA receptor binding : ISO:MGI
  • inositol 1,4,5 trisphosphate binding : IEA:InterPro
  • phosphatidylinositol phospholipase C activity : IEA:InterPro
GO - Biological process
  • gamma-aminobutyric acid signaling pathway : IGI:MGI
  • intracellular signal transduction : IEA:InterPro
  • lipid metabolic process : IEA:InterPro
  • positive regulation of receptor binding : IGI:MGI
  • regulation of peptidyl-serine phosphorylation : IGI:MGI
  • regulation of synaptic transmission, GABAergic : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.