DNA damage-binding protein 1 (Q3U1J4)

Uniprot ID Q3U1J4
Protein Name DNA damage-binding protein 1
Gene Name Ddb1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.608
Function Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2 (By similarity). .
GO - Molecular function
  • cullin family protein binding : ISO:MGI
  • damaged DNA binding : ISO:MGI
  • protein binding, bridging : ISO:MGI
  • protein-containing complex binding : ISO:MGI
  • WD40-repeat domain binding : ISO:MGI
GO - Biological process
  • cellular response to DNA damage stimulus : ISO:MGI
  • histone H2A monoubiquitination : ISO:MGI
  • interaction with symbiont : ISO:MGI
  • negative regulation of apoptotic process : IMP:MGI
  • nucleotide-excision repair : IBA:GO_Central
  • positive regulation by virus of viral protein levels in host cell : ISO:MGI
  • positive regulation of protein catabolic process : ISO:MGI
  • positive regulation of viral genome replication : ISO:MGI
  • positive regulation of viral release from host cell : ISO:MGI
  • proteasomal protein catabolic process : ISO:MGI
  • proteasome-mediated ubiquitin-dependent protein catabolic process : ISS:UniProtKB
  • protein ubiquitination : ISO:MGI
  • regulation of mitotic cell cycle phase transition : ISO:MGI
  • ubiquitin-dependent protein catabolic process : ISO:MGI
  • UV-damage excision repair : ISO:MGI
  • Wnt signaling pathway : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.