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Q3U1F9

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Q3U1F9)

Uniprot ID Q3U1F9
Protein Name Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Gene Name Pag1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (6) Interactions
Signal peptide(a) N Secretome P(b) 0.274
Function Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. .
GO - Molecular function
  • SH2 domain binding : ISO:MGI
  • transmembrane receptor protein tyrosine kinase adaptor activity : IBA:GO_Central
GO - Biological process
  • adaptive immune response : IEA:UniProtKB-KW
  • intracellular signal transduction : ISO:MGI
  • negative regulation of T cell activation : IDA:HGNC
  • regulation of T cell activation : ISO:MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.