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Q3TN34

MICAL-like protein 2 (Q3TN34)

Uniprot ID Q3TN34
Protein Name MICAL-like protein 2
Gene Name Micall2
Species Mus musculus (Mouse)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth. .
GO - Molecular function
  • actin filament binding : IDA:UniProtKB
  • actinin binding : IPI:UniProtKB
  • filamin binding : IDA:UniProtKB
  • metal ion binding : IEA:UniProtKB-KW
  • Rab GTPase binding : IPI:UniProtKB
GO - Biological process
  • actin cytoskeleton organization : IBA:GO_Central
  • actin cytoskeleton reorganization : IMP:UniProtKB
  • actin filament polymerization : IMP:UniProtKB
  • bicellular tight junction assembly : IMP:UniProtKB
  • endocytic recycling : IDA:MGI
  • neuron projection development : IMP:UniProtKB
  • substrate adhesion-dependent cell spreading : IMP:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.