Signal peptide(a) |
N |
Secretome P(b) |
0.386 |
Function |
ADP-ribosyltransferase (PubMed:27796300). By mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and subsequently decreasing STAT-1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to INFG stimulation (PubMed:27796300). Mono-ADP-ribosylates STAT6 (By similarity). Enhances STAT6-dependent transcription (PubMed:16537510). Positively regulates MRC1 expression in response to IL4 stimulation in macropahges by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (By similarity). . |
GO - Molecular function |
- enzyme binding : ISO:MGI
- NAD+ ADP-ribosyltransferase activity : ISO:MGI
- NAD+ binding : ISO:MGI
|
GO - Biological process |
- innate immune response : IEA:UniProtKB-KW
- negative regulation of gene expression : ISO:MGI
- negative regulation of interferon-gamma-mediated signaling pathway : IMP:UniProtKB
- negative regulation of tyrosine phosphorylation of STAT protein : ISO:MGI
- positive regulation of interleukin-4-mediated signaling pathway : IMP:UniProtKB
- positive regulation of tyrosine phosphorylation of STAT protein : ISO:MGI
- protein ADP-ribosylation : ISO:MGI
- protein poly-ADP-ribosylation : ISO:MGI
- regulation of transcription, DNA-templated : IEA:UniProtKB-KW
- transcription, DNA-templated : IEA:UniProtKB-KW
|