Poly [ADP-ribose] polymerase 14 (Q2EMV9)

Uniprot ID Q2EMV9
Protein Name Poly [ADP-ribose] polymerase 14
Gene Name Parp14
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.386
Function ADP-ribosyltransferase (PubMed:27796300). By mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and subsequently decreasing STAT-1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to INFG stimulation (PubMed:27796300). Mono-ADP-ribosylates STAT6 (By similarity). Enhances STAT6-dependent transcription (PubMed:16537510). Positively regulates MRC1 expression in response to IL4 stimulation in macropahges by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (By similarity). .
GO - Molecular function
  • enzyme binding : ISO:MGI
  • NAD+ ADP-ribosyltransferase activity : ISO:MGI
  • NAD+ binding : ISO:MGI
GO - Biological process
  • innate immune response : IEA:UniProtKB-KW
  • negative regulation of gene expression : ISO:MGI
  • negative regulation of interferon-gamma-mediated signaling pathway : IMP:UniProtKB
  • negative regulation of tyrosine phosphorylation of STAT protein : ISO:MGI
  • positive regulation of interleukin-4-mediated signaling pathway : IMP:UniProtKB
  • positive regulation of tyrosine phosphorylation of STAT protein : ISO:MGI
  • protein ADP-ribosylation : ISO:MGI
  • protein poly-ADP-ribosylation : ISO:MGI
  • regulation of transcription, DNA-templated : IEA:UniProtKB-KW
  • transcription, DNA-templated : IEA:UniProtKB-KW
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.