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Q15637

Splicing factor 1 (Q15637)

Uniprot ID Q15637
Protein Name Splicing factor 1
Gene Name SF1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. .
GO - Molecular function
  • identical protein binding : IPI:IntAct
  • pre-mRNA branch point binding : IEA:InterPro
  • RNA binding : HDA:UniProtKB
  • transcription corepressor activity : TAS:ProtInc
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • Leydig cell differentiation : IEA:Ensembl
  • male sex determination : IEA:Ensembl
  • mRNA 3'-splice site recognition : TAS:HGNC-UCL
  • mRNA splicing, via spliceosome : TAS:Reactome
  • negative regulation of smooth muscle cell proliferation : IEA:Ensembl
  • nuclear body organization : IEA:Ensembl
  • regulation of steroid biosynthetic process : IEA:Ensembl
  • spliceosomal complex assembly : NAS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.