| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. . |
| GO - Molecular function |
- DNA-binding transcription factor activity : IBA:GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific : ISA:NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific : IDA:NTNU_SB
- E-box binding : IDA:BHF-UCL
- protein C-terminus binding : IPI:UniProtKB
- protein dimerization activity : IEA:InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding : IDA:BHF-UCL
|
| GO - Biological process |
- cellular response to laminar fluid shear stress : NAS:BHF-UCL
- cellular response to low-density lipoprotein particle stimulus : IEP:BHF-UCL
- cellular response to starvation : IMP:ParkinsonsUK-UCL
- cholesterol homeostasis : IEA:Ensembl
- cholesterol metabolic process : IEA:UniProtKB-KW
- lipid metabolic process : TAS:ProtInc
- negative regulation of cholesterol efflux : IDA:BHF-UCL
- negative regulation of transcription by RNA polymerase II : IDA:NTNU_SB
- positive regulation of cholesterol storage : IDA:BHF-UCL
- positive regulation of pri-miRNA transcription by RNA polymerase II : IBA:GO_Central
- positive regulation of protein targeting to mitochondrion : HMP:ParkinsonsUK-UCL
- positive regulation of transcription by RNA polymerase II : IDA:UniProtKB
- regulation of autophagy of mitochondrion : HMP:ParkinsonsUK-UCL
- regulation of cholesterol biosynthetic process : TAS:Reactome
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter : IDA:BHF-UCL
- response to lipid : IBA:GO_Central
|