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Q10746

C-X-C motif chemokine 3 (Q10746)

Uniprot ID Q10746
Protein Name C-X-C motif chemokine 3
Gene Name Cxcl3
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (1) Interactions
Signal peptide(a) Y Secretome P(b)
Function Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. .
GO - Molecular function
  • chemokine activity : IDA:UniProtKB
  • CXCR chemokine receptor binding : IBA:GO_Central
GO - Biological process
  • antimicrobial humoral immune response mediated by antimicrobial peptide : ISO:RGD
  • cellular response to lipopolysaccharide : IEP:RGD
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • immune response : IBA:GO_Central
  • inflammatory response : IMP:RGD
  • killing of cells of other organism : ISO:RGD
  • leukocyte chemotaxis : IBA:GO_Central
  • neutrophil chemotaxis : IDA:UniProtKB
  • positive regulation of cytosolic calcium ion concentration : IDA:RGD
  • response to lipopolysaccharide : IEP:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.