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Q08749

Mitochondrial import inner membrane translocase subunit TIM18 (Q08749)

Uniprot ID Q08749
Protein Name Mitochondrial import inner membrane translocase subunit TIM18
Gene Name TIM18
Species Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. Its role in the complex is unclear but it may be involved in the assembly and stabilization of the TIM22 complex. .
GO - Molecular function
GO - Biological process
  • apoptotic process : IMP:SGD
  • cellular response to oxidative stress : IMP:SGD
  • oxidation-reduction process : IEA:GOC
  • protein insertion into mitochondrial inner membrane : IGI:SGD
  • protein transmembrane transport : IEA:GOC
  • response to arsenic-containing substance : IMP:SGD
  • response to osmotic stress : IMP:SGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.