| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. . |
| GO - Molecular function |
- DNA binding : ISO:MGI
- DNA-binding transcription factor activity : IBA:GO_Central
- protein N-terminus binding : ISO:MGI
- proximal promoter sequence-specific DNA binding : ISO:MGI
- transcription regulatory region sequence-specific DNA binding : IBA:GO_Central
- WW domain binding : ISO:MGI
|
| GO - Biological process |
- cell-cell signaling : IMP:MGI
- gene expression : IDA:MGI
- labyrinthine layer blood vessel development : IMP:MGI
- negative regulation of bone mineralization : IMP:MGI
- negative regulation of cell population proliferation : IDA:MGI
- negative regulation of syncytium formation by plasma membrane fusion : IMP:MGI
- positive regulation of peptidyl-lysine acetylation : IMP:MGI
- positive regulation of transcription, DNA-templated : IBA:GO_Central
- regulation of gene expression : IDA:MGI
- regulation of transcription by RNA polymerase II : IEA:InterPro
|