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Q03157

Amyloid-like protein 1 (Q03157)

Uniprot ID Q03157
Protein Name Amyloid-like protein 1
Gene Name Aplp1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. .
GO - Molecular function
  • alpha-2A adrenergic receptor binding : ISO:MGI
  • alpha-2B adrenergic receptor binding : ISO:MGI
  • alpha-2C adrenergic receptor binding : ISO:MGI
  • heparin binding : IEA:UniProtKB-KW
  • identical protein binding : ISO:MGI
  • transition metal ion binding : IEA:InterPro
GO - Biological process
  • apoptotic process : IEA:UniProtKB-KW
  • cell adhesion : IEA:UniProtKB-KW
  • cellular response to norepinephrine stimulus : ISO:MGI
  • endocytosis : IEA:UniProtKB-KW
  • extracellular matrix organization : IGI:MGI
  • forebrain development : IGI:MGI
  • mRNA polyadenylation : IDA:MGI
  • negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway : ISO:MGI
  • regulation of translation : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.