Ubiquitin-like modifier-activating enzyme 1 (Q02053)

Uniprot ID Q02053
Protein Name Ubiquitin-like modifier-activating enzyme 1
Gene Name Uba1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.56
Function Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1511901). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • ubiquitin activating enzyme activity : IDA:MGI
GO - Biological process
  • cellular response to DNA damage stimulus : ISO:MGI
  • ubiquitin-dependent protein catabolic process : IBA:GO_Central
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.