Tyrosine-protein kinase RYK (Q01887)

Uniprot ID Q01887
Protein Name Tyrosine-protein kinase RYK
Gene Name Ryk
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b)
Function May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • frizzled binding : IPI:UniProtKB
  • protein kinase activity : IEA:InterPro
  • transmembrane signaling receptor activity : ISO:MGI
  • Wnt-activated receptor activity : IPI:MGI
  • Wnt-protein binding : IPI:UniProtKB
GO - Biological process
  • axon guidance : IDA:UniProtKB
  • axonogenesis : IGI:MGI
  • chemorepulsion of axon : TAS:ParkinsonsUK-UCL
  • chemorepulsion of dopaminergic neuron axon : IGI:ParkinsonsUK-UCL
  • commissural neuron axon guidance : IMP:MGI
  • corpus callosum development : IMP:UniProtKB
  • midbrain dopaminergic neuron differentiation : IMP:ParkinsonsUK-UCL
  • negative chemotaxis : IGI:MGI
  • negative regulation of axon extension involved in axon guidance : IGI:MGI
  • nervous system development : IBA:GO_Central
  • neuron differentiation : IDA:UniProtKB
  • neuron projection development : IMP:UniProtKB
  • peptidyl-tyrosine phosphorylation : IEA:GOC
  • planar cell polarity pathway involved in axon guidance : IGI:ParkinsonsUK-UCL
  • positive regulation of MAPK cascade : ISS:UniProtKB
  • skeletal system morphogenesis : IMP:MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway : IBA:GO_Central
  • Wnt signaling pathway : IDA:UniProtKB
  • Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation : ISS:ParkinsonsUK-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.