| Signal peptide(a) |
N |
Secretome P(b) |
0.744 |
| Function |
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. |
| GO - Molecular function |
- coenzyme binding : ISO:MGI
- hydroxymethylglutaryl-CoA reductase (NADPH) activity : IDA:MGI
- hydroxymethylglutaryl-CoA reductase activity : ISO:MGI
- NADPH binding : ISO:MGI
- protein homodimerization activity : ISO:MGI
- protein phosphatase 2A binding : ISO:MGI
|
| GO - Biological process |
- aging : IEA:Ensembl
- cholesterol biosynthetic process : IDA:MGI
- coenzyme A metabolic process : IEA:InterPro
- isoprenoid biosynthetic process : ISO:MGI
- myoblast differentiation : IEA:Ensembl
- negative regulation of apoptotic process : ISO:MGI
- negative regulation of blood vessel diameter : ISO:MGI
- negative regulation of insulin secretion involved in cellular response to glucose stimulus : ISO:MGI
- negative regulation of MAP kinase activity : IGI:MGI
- negative regulation of striated muscle cell apoptotic process : ISO:MGI
- negative regulation of wound healing : ISO:MGI
- positive regulation of cardiac muscle cell apoptotic process : ISO:MGI
- positive regulation of cell proliferation : ISO:MGI
- positive regulation of ERK1 and ERK2 cascade : ISO:MGI
- positive regulation of skeletal muscle tissue development : ISO:MGI
- positive regulation of smooth muscle cell proliferation : ISO:MGI
- positive regulation of stress-activated MAPK cascade : ISO:MGI
- protein tetramerization : ISO:MGI
- response to ethanol : IEA:Ensembl
- response to nutrient : IEA:Ensembl
- ubiquinone metabolic process : ISO:MGI
- visual learning : IGI:MGI
|