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Q00981

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (Q00981)

Uniprot ID Q00981
Protein Name Ubiquitin carboxyl-terminal hydrolase isozyme L1
Gene Name Uchl1
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (14) Interactions
Signal peptide(a) N Secretome P(b)
Function Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (By similarity). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity). .
GO - Molecular function
  • alpha-2A adrenergic receptor binding : ISO:RGD
  • cysteine-type endopeptidase activity : ISO:RGD
  • ligase activity : IEA:InterPro
  • omega peptidase activity : ISO:RGD
  • thiol-dependent ubiquitin-specific protease activity : ISO:RGD
  • ubiquitin binding : ISO:RGD
  • ubiquitin protein ligase binding : ISO:RGD
GO - Biological process
  • adult walking behavior : ISO:RGD
  • axon target recognition : ISO:RGD
  • axonal transport of mitochondrion : ISO:RGD
  • axonogenesis : ISO:RGD
  • cell population proliferation : ISO:RGD
  • cellular response to drug : IEA:Ensembl
  • eating behavior : ISO:RGD
  • muscle fiber development : ISO:RGD
  • negative regulation of MAP kinase activity : ISO:RGD
  • neuromuscular process : ISO:RGD
  • protein deubiquitination : ISO:RGD
  • response to ischemia : ISO:RGD
  • sensory perception of pain : IDA:RGD
  • ubiquitin-dependent protein catabolic process : IDA:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.