Interleukin-6 receptor subunit beta (Q00560)

Uniprot ID	Q00560
Protein Name	Interleukin-6 receptor subunit beta
Gene Name	Il6st
Species	Mus musculus (Mouse)

Signal peptide^(a)	Y	Secretome P^(b)	0.214
Function	Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:1602143). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Does not bind IL6 (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596). .
GO - Molecular function	ciliary neurotrophic factor receptor activity : ISO:MGI ciliary neurotrophic factor receptor binding : ISO:MGI growth factor binding : ISO:MGI interleukin-6 binding : IEA:Ensembl interleukin-6 receptor activity : IEA:Ensembl interleukin-6 receptor binding : IEA:Ensembl leukemia inhibitory factor receptor activity : IEA:Ensembl oncostatin-M receptor activity : IEA:Ensembl protein heterodimerization activity : ISO:MGI
GO - Biological process	ciliary neurotrophic factor-mediated signaling pathway : ISO:MGI cytokine-mediated signaling pathway : IDA:MGI glycogen metabolic process : IMP:MGI interleukin-11-mediated signaling pathway : IEA:GOC interleukin-27-mediated signaling pathway : ISO:MGI interleukin-6-mediated signaling pathway : ISO:MGI leukemia inhibitory factor signaling pathway : ISO:MGI negative regulation of cytosolic calcium ion concentration : ISO:MGI negative regulation of interleukin-6-mediated signaling pathway : ISO:MGI oncostatin-M-mediated signaling pathway : ISO:MGI positive regulation of astrocyte differentiation : IMP:MGI positive regulation of cell proliferation : IGI:MGI positive regulation of osteoblast differentiation : ISO:MGI positive regulation of smooth muscle cell migration : ISO:MGI positive regulation of T cell proliferation : ISO:MGI positive regulation of tyrosine phosphorylation of STAT protein : ISO:MGI regulation of Notch signaling pathway : IDA:MGI response to cytokine : ISO:MGI signal transduction : IDA:MGI triglyceride mobilization : ISO:MGI

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}